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Trazodone Side Effects

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March 13, 2025

Trazodone Side Effects: What You Need to Know Before Using It for Sleep

Medically reviewed by: 

Dr. Shiyan Ooi

School of Medical Sciences, University of Manchester

Trazodone is a commonly prescribed medication for depression, but it is also frequently used off-label as a sleep aid. While it can help with sleep problems, trazodone comes with potential side effects that users should be aware of before using it.

Common Side Effects of Trazodone

Most individuals who take trazodone for sleep may experience mild to moderate side effects, including:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Headaches
  • Blurred vision

These effects typically diminish as the body adjusts to the medication (National Institutes of Health).

Serious Side Effects and Risks

In some cases, trazodone can lead to more severe reactions. These may include:

  • Low blood pressure (hypotension)
  • Heart rhythm irregularities
  • Confusion or cognitive impairment
  • Increased risk of falls, especially in older adults
  • Priapism (a rare but serious prolonged erection in men)

If you experience any of these serious side effects, seek immediate medical attention (FDA).

Long-Term Risks of Using Trazodone for Sleep

Although trazodone is not classified as a controlled substance, prolonged use may lead to dependence or tolerance. Additionally, some research suggests a possible link between long-term use of sedating medications and cognitive decline.

Who Should Avoid Trazodone?

Trazodone may not be suitable for individuals with:

  • Heart disease or arrhythmias
  • Low blood pressure
  • History of priapism
  • Severe kidney or liver conditions

It's important to discuss your medical history with a healthcare provider before taking trazodone for sleep.

Alternative Sleep Solutions

For those seeking a medication-free way to improve sleep, Cognitive Behavioral Therapy for Insomnia (CBT-I) is a highly effective option. Sleep Reset provides a science-backed, drug-free approach to improving sleep patterns naturally.

Conclusion

While trazodone can be effective for sleep, it is essential to weigh its benefits against the potential side effects and long-term risks. Consult a healthcare provider before using trazodone and explore alternative solutions for lasting sleep improvements.

Dr. Shiyan Ooi

Dr. Shiyan Ooi is a medical doctor with over a decade of experience treating patients with chronic conditions. She graduated from the University of Manchester with a Bachelor of Medicine and Surgery (MBChB UK) and spent several years working at the National Health Service (NHS) in the United Kingdom, several Singapore government hospitals, and private functional medicine hospitals. Dr. Ooi specializes in root cause analysis, addressing hormonal, gut health, and lifestyle factors to treat chronic conditions. Drawing from her own experiences, she is dedicated to empowering others to optimize their health. She loves traveling, exploring nature, and spending quality time with family and friends.