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Medically reviewed by:
Dr. Shiyan Ooi
,
School of Medical Sciences, University of Manchester
Trazodone is an antidepressant that is commonly prescribed off-label to treat insomnia. While it can be effective in promoting sleep, questions remain about its long-term safety and potential side effects.
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It works by increasing serotonin levels in the brain, which can help regulate mood and promote relaxation. Unlike traditional sleep aids, trazodone does not work by suppressing the central nervous system but rather by modifying neurotransmitter activity (National Institutes of Health).
Studies have shown that trazodone can help individuals fall asleep faster and stay asleep longer. It is particularly beneficial for those who have difficulty maintaining sleep rather than those who struggle to fall asleep initially. However, trazodone is not FDA-approved for insomnia, and its effectiveness varies among individuals.
Like all medications, trazodone comes with potential side effects, including:
In some cases, trazodone may also cause more severe effects such as low blood pressure, heart rhythm abnormalities, or priapism, a rare but serious condition in men (FDA).
While trazodone is often prescribed for extended periods, its long-term safety for sleep disorders is still being studied. Some concerns include:
Patients should consult with their healthcare provider before using trazodone long-term.
For those looking for a drug-free approach to improving sleep, Cognitive Behavioral Therapy for Insomnia (CBT-I) is a proven method. Sleep Reset offers evidence-based CBT-I techniques to help individuals manage sleep disorders naturally.
Trazodone can be an effective sleep aid, but its long-term safety remains uncertain. Those considering trazodone for chronic insomnia should discuss the risks and benefits with their doctor or explore non-medication alternatives for better sleep health.
Dr. Shiyan Ooi
Dr. Shiyan Ooi is a medical doctor with over a decade of experience treating patients with chronic conditions. She graduated from the University of Manchester with a Bachelor of Medicine and Surgery (MBChB UK) and spent several years working at the National Health Service (NHS) in the United Kingdom, several Singapore government hospitals, and private functional medicine hospitals. Dr. Ooi specializes in root cause analysis, addressing hormonal, gut health, and lifestyle factors to treat chronic conditions. Drawing from her own experiences, she is dedicated to empowering others to optimize their health. She loves traveling, exploring nature, and spending quality time with family and friends.
