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L-Theanine vs. Melatonin: Which One Should You Take for Sleep?

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March 13, 2025

L-Theanine vs. Melatonin: Which One Should You Take for Sleep?

Medically reviewed by: 

Dr. Shiyan Ooi

School of Medical Sciences, University of Manchester

When it comes to improving sleep quality, both L-Theanine and melatonin are popular natural supplements. However, they work in different ways. Understanding their differences can help determine which one is right for you.

How L-Theanine Works

L-Theanine is an amino acid found in tea leaves that promotes relaxation without causing drowsiness. It works by:

           
  • Increasing alpha brain waves, which encourage a calm state
  •        
  • Enhancing GABA, serotonin, and dopamine production
  •        
  • Reducing stress and anxiety
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L-Theanine is best for those who struggle with stress-induced sleep disturbances (National Institutes of Health).

How Melatonin Works

Melatonin is a hormone naturally produced by the body to regulate sleep-wake cycles. Supplementing with melatonin can help by:

           
  • Signaling the body that it's time to sleep
  •        
  • Resetting circadian rhythms for those with jet lag or shift work
  •        
  • Improving sleep onset for individuals with insomnia
  •    

Melatonin is ideal for those who have trouble falling asleep due to irregular schedules (National Institutes of Health). However melatonin also comes with certain side effects.

Which One Should You Take?

If stress and anxiety keep you awake, L-Theanine may be the better option. If you have trouble falling asleep due to circadian rhythm disruptions, melatonin might be more effective.

Conclusion

Both L-Theanine and melatonin offer unique sleep benefits. Choosing the right one depends on your specific sleep concerns and how your body responds to each supplement.

Dr. Shiyan Ooi

Dr. Shiyan Ooi is a medical doctor with over a decade of experience treating patients with chronic conditions. She graduated from the University of Manchester with a Bachelor of Medicine and Surgery (MBChB UK) and spent several years working at the National Health Service (NHS) in the United Kingdom, several Singapore government hospitals, and private functional medicine hospitals. Dr. Ooi specializes in root cause analysis, addressing hormonal, gut health, and lifestyle factors to treat chronic conditions. Drawing from her own experiences, she is dedicated to empowering others to optimize their health. She loves traveling, exploring nature, and spending quality time with family and friends.