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GABA vs. Melatonin: Which Works Better for Insomnia?

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March 13, 2025

GABA vs. Melatonin: Which Works Better for Insomnia?

Medically reviewed by: 

Dr. Shiyan Ooi

School of Medical Sciences, University of Manchester

GABA and melatonin are two popular supplements used to improve sleep, but they work in different ways. Understanding their effects can help determine which one is best for treating insomnia.

How GABA Works for Sleep

GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter that helps slow down brain activity and promote relaxation. It works by:

           
  • Reducing stress and anxiety
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  • Promoting a calm state of mind
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  • Shortening sleep onset time
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Some studies suggest that increased GABA levels improve sleep quality and reduce nighttime awakenings (National Institutes of Health).

How Melatonin Works for Sleep

Melatonin is a hormone naturally produced by the body to regulate the sleep-wake cycle. Supplementing with melatonin can help by:

           
  • Signaling the body that it's time to sleep
  •        
  • Regulating circadian rhythms
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  • Helping with jet lag and shift work sleep disorders
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Melatonin is most effective for people with sleep onset insomnia or circadian rhythm disruptions (National Institutes of Health). However, melatonin also comes with certain side effects.

Which One Should You Choose?

If stress and anxiety keep you awake, GABA may be a better option. If you struggle with falling asleep due to an irregular schedule, melatonin could be more effective.

Conclusion

Both GABA and melatonin provide sleep benefits, but they target different causes of insomnia. Choosing the right one depends on your individual sleep concerns and how your body responds to each supplement.

Dr. Shiyan Ooi

Dr. Shiyan Ooi is a medical doctor with over a decade of experience treating patients with chronic conditions. She graduated from the University of Manchester with a Bachelor of Medicine and Surgery (MBChB UK) and spent several years working at the National Health Service (NHS) in the United Kingdom, several Singapore government hospitals, and private functional medicine hospitals. Dr. Ooi specializes in root cause analysis, addressing hormonal, gut health, and lifestyle factors to treat chronic conditions. Drawing from her own experiences, she is dedicated to empowering others to optimize their health. She loves traveling, exploring nature, and spending quality time with family and friends.